Therapeutic indications
It is indicated to adjust the equilibrium of humour electrolyte acid and alkali, Used for metabolic acid toxicosis or dehydration caused by metabolic acid toxicosis.

Posology and method of administration

By phleboclysis. The general dose for the adult is 500-1000ml/time, but the dose can be reduced or increased according to the avoirdupois and the age. The speed of administration is 300~500ml/hour.

Contraindications:

Solutions containing lactate are NOT FOR USE IN THE TREATMENT OF LACTIC ACIDOSIS.

Special warning and precautions for use:

Interaction with other medicinal products and other forms of Interactions

[Pregnancy and Lactation]
The administration may intensify edema or raise the blood pressure for the gravida have pregnancy toxinosis
[Pediatric Use]
Calculate the dose according to the age and body weight
[Geratology]
For the old patients usually have insidious cardiac insufficiency or renal inadequacy, so it is must be used carefully..

Effects on ability to drive and use machine
Not applicable.

Undesirable effects

1. For the patients with hepo-calcium ( such as uraemia) , after correcting acid toxicosis the following cases may happen: limb tingling, ache, twitch, dyspnea and so on. The cause is the reduction of concentration of blood serum calcium ion.
2. Cardioacceleration, chest distress, breath lessness, pulmonary edema, heart failure and etc.
3. Blood pressure arise.
4. Body weight rise,  edema.
5. Over dose may lead to alkali poisoning. 
6. The potassium’s concentration decline, sometimes hepopotassaemia may happen.

 

Overdose and special antidotes

Overdose may lead to edema or lose balance of ion in body.

Pharmacological Properties :
Pharmacodynamic Properties
In the natural case our blood contain a little lactic acid, it is mainly produced by dextrose or hepatin through zymohydrolysis happening in muscle, skin, brain and cell. After the production of lactate, lactic acid will be translated into hepatin or pyruvic acid , or come into tricabroxylic acid circle , be decomposed to water and carbon dioxide. So the last metabolize production is sodium bicarbonate, it can correct metabolizable acid toxicosis. When the product is indicated for hyperpotassaemia following   acidosis , sodium lactate can correct acid toxicosis, and make the potassium come into the cell from blood or extracellular fluid. The main viscera that can decompose lactic acid is liver and kidney. When the metabolize of lactic acid is abnormal or out of gear, the curative effect is not very good.

Pharmacokinetic Properties
pH of sodium lactate is 6.5-7.5, it can be absorbed quickly after taking orally , and can be oxidationed by liver in 1-2 hour, with the metabolism products sodium bicarbonate. But it is usually administered by phleboclysis. Using sodium lactate instead of sodium acetate as the buffer for peritoneum dialyszte can reduce the excitation for peritoneum, it can also reduce the influence for depression of cardiac muscle and the resistance of the around blood vessel .